ck5/6 positive meaning breast cancer

Release time ：Dec-28,2024

CK5/6 is a cytokeratin protein, and its positive expression is typically linked to certain subtypes of breast cancer. A positive CK5/6 status may indicate that the tumor is more aggressive and less responsive to certain therapeutic approaches.

Breast cancers that are CK5/6-positive often encompass triple-negative breast cancer and specific types such as basal-like breast cancer. These subtypes frequently lack effective targeted therapies, leading to a reliance on chemotherapy and radiotherapy as primary treatment modalities. Despite standard treatments, the prognosis for patients with these tumors remains poor due to their aggressive nature and high risk of recurrence. Furthermore, CK5/6-positive breast cancers may also be associated with BRCA1 gene mutations, adding to the therapeutic challenges.

For patients with CK5/6-positive breast cancer, regular medical check-ups are advised to identify and address any potential recurrence or metastasis promptly. Patients should adhere to their physicians' recommendations, undergo appropriate treatment regimens, and stay informed about emerging treatment options or clinical trials. Throughout the treatment journey, maintaining healthy lifestyle practices, including a balanced diet, regular exercise, and abstaining from smoking, is crucial for enhancing treatment outcomes and overall quality of life.