breast cancer stem cells

Release time ：Dec-27,2024

Breast cancer stem cells possess self-renewal and differentiation capabilities, playing a pivotal role in the initiation, progression, and metastasis of breast cancer. Their presence complicates breast cancer treatment, as conventional therapies may fail to eradicate these stem cells entirely, potentially leading to cancer relapse.

Research into breast cancer stem cells has uncovered their interplay with the tumor microenvironment and their mechanisms of resistance to chemotherapy and radiotherapy. For instance, these stem cells can bolster their survival by activating specific signal pathways or evade treatment effects by altering their metabolic state. Moreover, they can secrete a range of factors that remodel the tumor microenvironment, further promoting tumor growth and dissemination.

In light of the unique traits of breast cancer stem cells, researchers are developing novel therapeutic strategies aimed at more effectively targeting these cells. This includes the creation of antibodies against specific breast cancer stem cell markers, small molecule inhibitors that disrupt their signaling pathways, and the utilization of immunotherapies to enhance the body's ability to recognize and eliminate breast cancer stem cells. These innovative approaches offer renewed hope for breast cancer patients, though further clinical trials are necessary to confirm their safety and efficacy. Consequently, for individuals diagnosed with breast cancer, timely medical consultation and adherence to standardized, comprehensive treatment protocols remain paramount.