ovarian suppression in breast cancer

Release time ：Dec-24,2024

Ovarian suppression in breast cancer is a therapeutic approach aimed at reducing estrogen levels to slow or halt tumor progression. It is primarily indicated for patients with hormone receptor-positive breast cancer, particularly those who have not yet reached menopause.

Ovarian suppression can be achieved through various methods, ranging from less to more invasive and from common to less common practices. One common surgical approach is oophorectomy, the removal of the ovaries, which is effective but can result in immediate menopause. Another method involves the use of medications to inhibit ovarian function, such as gonadotropin-releasing hormone (GnRH) agonists, which can temporarily deactivate the ovaries and decrease estrogen production. These medications, however, may cause menopausal symptoms like hot flashes and vaginal dryness. In some cases, doctors might consider radiotherapy or chemotherapy to indirectly impact ovarian function, potentially leading to permanent or temporary damage to the ovaries and a subsequent reduction in estrogen levels.

Patients undergoing ovarian suppression for breast cancer should adhere to their physician's advice, be informed about their treatment options, and discuss possible side effects and their management. Regular check-ups are essential during treatment to allow doctors to monitor changes in ovarian function and adjust the treatment plan as necessary. Additionally, maintaining a healthy lifestyle, including a balanced diet, regular exercise, and avoiding smoking, can contribute to better therapeutic outcomes and overall quality of life.