chek2 gene and breast cancer

Release time ：Dec-18,2024

The Chek2 gene is commonly recognized as a risk factor for breast cancer. Research indicates that individuals with certain Chek2 gene mutations have a higher lifetime risk of developing breast cancer compared to those without these mutations.

The Chek2 gene encodes the Chek2 protein, which is crucial in cell cycle regulation, particularly in DNA damage repair. Mutations in the Chek2 gene may impair the cell's ability to effectively repair DNA damage, increasing the risk of malignant transformation. Studies have identified specific Chek2 gene mutations, such as the I157T mutation, that are significantly correlated with an increased risk of breast cancer. However, not all Chek2 mutations result in breast cancer, and an individual's actual risk is influenced by additional genetic and environmental factors.

For individuals known to carry Chek2 gene mutations, regular breast cancer screening is essential. Additionally, adopting a healthy lifestyle, including a balanced diet, regular exercise, and avoiding smoking, can help reduce the risk of breast cancer. Those with a family history of breast cancer or other risk factors should consult a physician to develop a personalized prevention and surveillance plan.