breast cancer glycolysis

Release time ：Dec-16,2024

Glycolysis in breast cancer denotes the aberrant reliance of tumor cells on glucose for energy metabolism. This phenomenon is recognized as the Warburg effect, indicating that cancer cells preferentially utilize glycolysis to generate energy even in the presence of ample oxygen, instead of the more efficient mitochondrial respiratory chain.

Glycolysis plays a multifaceted role in the progression of breast cancer. Primarily, it offers a swift source of energy, facilitating rapid cancer cell proliferation. Additionally, intermediates from glycolysis can act as precursors for the synthesis of macromolecules essential for cell growth, including amino acids, fatty acids, and nucleotides. Furthermore, glycolysis contributes to the modulation of intracellular signaling pathways, influencing cell survival, proliferation, and migration. However, an overreliance on glycolysis can heighten cancer cells' sensitivity to metabolic inhibitors, presenting opportunities for devising novel therapeutic strategies.

Considering the glycolytic traits of breast cancer, patients should maintain a healthy dietary regimen in their daily lives, steering clear of high-sugar and high-fat foods to curtail the energy supply to cancer cells. Regular health check-ups are also crucial for closely monitoring one's health status, with prompt medical consultation in case of any detected abnormalities. Throughout treatment, patients are advised to adhere to medical guidance, sensibly alter their lifestyle and dietary habits, and actively collaborate with physicians for a comprehensive therapeutic approach.